Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor

FEBS Letters

Altar, C.Anthony¹  Tandon, Narendra N¹  Nakahashi, Takeshi¹  Fujimura, Hironobu¹  Kambayashi, Jun-ichi¹  Li, Jess¹  Sun, Bing¹ 

[1] Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA

关键词: Neurotrophin;    Human umbilical vein endothelial cell;    cAMP;    Platelet;   

DOI  :  10.1016/S0014-5793(00)01302-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair after injury. BDNF has been detected in rat and human blood, but the source of circulating BDNF is not established. BDNF messenger and peptide were detected in cultured cells and in the culture medium of human umbilical vein endothelial cells. The expression of BDNF was up-regulated by elevation of intracellular cAMP and down-regulated by Ca²⁺ ionophore, bovine brain extract and laminar fluid shear stress. These results suggest that vascular endothelial cells may contribute to circulating BDNF.

【 授权许可】

Unknown