Rab37 is a novel mast cell specific GTPase localized to secretory granules

FEBS Letters

Shen, Mary¹  Young, Chi¹  Luo, Ying¹  Payan, Don G.¹  Yu, Sandra¹  Bennett, Mark K.¹  Scheller, Richard H.²  Masuda, Esteban S.¹  Rossi, Alex B.¹  Huang, Betty C.B.¹ 

[1] Rigel Inc., 240 East Grand Avenue, South San Francisco, CA 94080, USA;Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA

关键词: GTPase;    Exocytosis;    Mast cell;    Allergy;   

DOI  :  10.1016/S0014-5793(00)01288-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

GTPases regulate a myriad of cellular functions including signal transduction, cytoskeletal organization and membrane trafficking. Rab GTPases act to coordinate the membrane dynamics of cells by organizing and regulating the activity of effector proteins important in vesicle trafficking. Rab37 is a novel Rab GTPase specifically expressed in the MC-9 mast cell line and bone marrow mast cells. Rab37 is 74% identical to Rab26 and 47% identical to Rab8, a GTPase important in Golgi to plasma membrane vesicle trafficking in mammalian cells. When green fluorescent protein tagged Rab37 is expressed in bone marrow mast cells, the secretory granules are labeled. These data suggest that Rab37 may play an important role in mast cell degranulation making this protein a potentially important target for therapeutic intervention in the treatment of allergy.

【 授权许可】

Unknown