Rab27a, actin and beta-cell endocytosis [Review]

Endocrine Journal

Toshihide Kimura¹  Ichiro Niki¹ 

[1] Department of Pharmacology, Oita University Faculty of Medicine, Oita, Japan

关键词: Rab27a;    Coronin;    GTPase;    Endocytosis;    Exocytosis;   

DOI  :  10.1507/endocrj.K10E-391

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(43)Cited-By(5)The output and time-course of insulin release from pancreatic beta-cells are elegantly controlled.The secretory process comprises pre-exocytotic stages, exocytosis and post-exocytotic stages.The small GTPase Rab27a is known to regulate pre-exocytotic stages that determine the size of the readily-releasable pool of insulin granules.GTP-Rab27a and its specific effectors are responsible for this process like other GTPases.Recently, we searched for Rab27a-interacting proteins and identified coronin 3.Unexpectedly, coronin 3 only bound GDP-Rab27a and this interaction regulated post-exocytotic stages via reorganization of the actin cytoskeleton.Since glucose converts Rab27a from the GTP- to GDP-bound form, we suggested that Rab27a plays a crucial role in stimulus-endocytosis coupling in pancreatic beta-cells, and that this is the key molecule for membrane recycling of insulin granules.In this review, we provide an overview of the roles of Rab27a and its GTP- and GDP-dependent effectors in the insulin secretory pathway of pancreatic beta-cells.

【 授权许可】

Unknown