Cell swelling activates STAT1 and STAT3 proteins in cultured rat hepatocytes

FEBS Letters

Meisse, Delphine²  Dusanter-Fourt, Isabelle¹  Husson, Annie²  Lavoinne, Alain² 

[1]U-363 INSERM, ICGM, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France

[2]Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle (GBPDN), Institut Fédératif de Recherche Multidisciplinaire sur les Peptides no. 23 (IFRMP), UFR Médecine-Pharmacie de Rouen, 22 boulevard Gambetta, 76183 Rouen Cedex, France

关键词: STAT protein;    Hypoosmolarity;    α2-Macroglobulin;    Interleukin-6;    Swelling;    Hepatocyte;   

DOI  :  10.1016/S0014-5793(99)01643-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this paper, we demonstrated that in cultured rat hepatocytes cell swelling induced the activation of STAT1 and STAT3 proteins without any effect on STAT4, STAT5 and STAT6 proteins. Cell swelling induced an activation of STAT proteins through an increase in the phosphorylation of the tyrosine residue also phosphorylated by interleukin-6, but without any activation of JAK kinases. The signaling pathway by which cell swelling activated STAT1 and STAT3 is discussed.

【 授权许可】

Unknown