IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

FEBS Letters

Richard, Yolande¹  Rolling, Christine¹  Galanaud, Pierre¹  Treton, Dominique¹  Pellegrini, Sandra² 

[1] INSERM U131, Institut Paris-Sud sur les Cytokines, 32 rue des Carnets, 92140 Clamart, France;INSERM U 276, Institut Pasteur, Paris, France

关键词: Human B cell;    IL13 signalling;    IL4Rα;    IL2Rγc;    STAT protein;   

DOI  :  10.1016/0014-5793(96)00835-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4Rα and IL2Rγc are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

【 授权许可】

Unknown