SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

FEBS Letters

Okada, Masato¹  Nagai, Katsuya¹  Takano, Atsuko¹  Shimizu, Kimiko¹ 

[1] Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3-2 Yamada-Oka, Suita, Osaka 565-0871, Japan

关键词: Circadian rhythm;    Differential display;    Suprachiasmatic nucleus;    Leucine-rich repeat;    Protein phosphatase 2C;    Rat brain;   

DOI  :  10.1016/S0014-5793(99)01190-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (CN ircadian scillatory rotein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN.

【 授权许可】

Unknown