Aqp5 expression in salivary glands" /> 期刊论文

期刊论文详细信息
The journal of physiological sciences: JPS
The central clock controls the daily rhythm of Aqp5 expression in salivary glands
Nana N. Takasu1  Hitoshi Uchida2  Takahiro J. Nakamura3  Aya Obana-Koshino4 
[1] Meiji University;Nagasaki University Graduate School of Biomedical Sciences;Osaka University;Teikyo Heisei University
关键词: Circadian rhythm;    Salivary gland;    Suprachiasmatic nucleus;    Aquaporin 5;    Period 2;   
DOI  :  10.1007/s12576-017-0540-1
学科分类:生理学
来源: Springer
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【 摘 要 】

Salivary secretion displays day–night variations that are controlled by the circadian clock. The central clock in the suprachiasmatic nucleus (SCN) regulates daily physiological rhythms by prompting peripheral oscillators to adjust to changing environments. Aquaporin 5 (Aqp5) is known to play a key role in salivary secretion, but the association between Aqp5 and the circadian rhythm is poorly understood. The aim of our study was to evaluate whether Aqp5 expression in submandibular glands (SMGs) is driven by the central clock in the SCN or by autonomous oscillations. We observed circadian oscillations in the activity of period circadian protein homolog 2 and luciferase fusion protein (PER2::LUC) in cultured SMGs with periodicity depending on core clock genes. A daily rhythm was detected in the expression profiles of Aqp5 in SMGs in vivo. In cultured SMGs ex vivo, clock genes showed distinct circadian rhythms, whereas Aqp5 expression did not. These data indicate that daily Aqp5 expression in the mouse SMG is driven by the central clock in the SCN.

【 授权许可】

CC BY   

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