The 3′ non‐coding region of the Drosophila melanogaster HeT‐A telomeric retrotransposon contains sequences with propensity to form G‐quadruplex DNA

FEBS Letters

Villasante, Alfredo¹  Abad, José P.¹ 

[1]Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), 28049 Madrid, Spain

关键词: G-quadruplex DNA;    HeT-A element;    Telomere;    Centromere;    Drosophila;   

DOI  :  10.1016/S0014-5793(99)00695-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

HeT-A elements are non-long terminal repeat retrotransposons added onto the Drosophila chromosome ends. We have investigated the formation in vitro of higher order structures by oligonucleotides derived from the 3′ non-coding region of HeT-A elements and found that they are capable of forming G-quadruplex DNA. These results suggest that the 3′ repeat region of HeT-A may structurally behave as the telomeric repeats common to a majority of eukaryotes. The presence of structural motifs shared by telomeres and centromeres and the implications of these findings for chromosome evolution are discussed.

【 授权许可】

Unknown