Protein kinases in control of the centrosome cycle

FEBS Letters

Fry, Andrew M.³  Nigg, Erich A.¹  Stierhof, York-Dieter²  Mayor, Thibault¹  Meraldi, Patrick¹ 

[1] Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland;Abteilung Membranbiochemie, Max-Planck-Institut fur Biologie, 72076 Tubingen, Germany;Department of Biochemistry, University of Leicester, Leicester LE1 7RH, UK

关键词: Centrosome;    Cell cycle;    Polo;    NIMA;    NIMA-related kinase 2;    Centrosomal NIMA-related kinase 2-associated protein 1;   

DOI  :  10.1016/S0014-5793(99)00534-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The centrosome is the major microtubule nucleating center of the animal cell and forms the two poles of the mitotic spindle upon which chromosomes are segregated. During the cell division cycle, the centrosome undergoes a series of major structural and functional transitions that are essential for both interphase centrosome function and mitotic spindle formation. The localization of an increasing number of protein kinases to the centrosome has revealed the importance of protein phosphorylation in controlling many of these transitions. Here, we focus on two protein kinases, the polo-like kinase 1 and the NIMA-related kinase 2, for which recent data indicate key roles during the centrosome cycle.

【 授权许可】

Unknown