Molecular analysis of a new splice variant of the human melanocortin‐1 receptor

FEBS Letters

Howard, Andrew D¹  Tan, Carina P¹  MacNeil, Douglas J¹  Weinberg, David H¹  Feighner, Scott D¹  Kulju McKee, Karen¹  Van Der Ploeg, Lex H.T¹  Hreniuk, Donna L¹  Palyha, Oksana C¹  MacNeil, Tanya¹ 

[1] Department of Metabolic Disorders, Merck Research Laboratories, Building RY-80Y-265, P.O. Box 2000, Rahway, NJ 07065, USA

关键词: Melanocortin;    G-protein-coupled receptor;    Pigmentation;   

DOI  :  10.1016/S0014-5793(99)00525-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The primary hormonal regulator of pigmentation is melanocyte stimulating hormone derived from proopiomelanocortin by proteolytic processing. The melanocortin-1 receptor serves a key role in the regulation of pigmentation. We describe the identification of the first intron within a melanocortin receptor. A new melanocortin-1 receptor isoform, generated by alternative mRNA splicing, encodes an additional 65 amino acids at the predicted intracellular, C-terminal tail of the melanocortin-1 receptor. When expressed in heterologous cells, the new spliced form of the melanocortin-1 receptor (melanocortin-1 receptor B) appears pharmacologically similar to the non-spliced melanocortin-1 receptor. Melanocortin-1 receptor B is expressed in testis, fetal heart and melanomas.

【 授权许可】

Unknown