Recognizing the Pleckstrin homology domain fold in mammalian phospholipase D using hidden Markov models

FEBS Letters

Beaven, Michael A¹  Geetha, V²  Munson, Peter J²  Holbrook, Pamela G¹ 

[1] Laboratory of Molecular Immunology, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 8N-109, Bethesda, MD 20892, USA;Analytical Biostatistics Section, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Building 12A, Room 2041, Bethesda, MD 20892, USA

关键词: Phospholipase D;    Pleckstrin homology domain;    Hidden Markov models;    Phosphatidylinositol-3;    4;    5-trisphosphate binding protein;    β-Adrenergic receptor kinase;    Lipid signalling;   

DOI  :  10.1016/S0014-5793(99)00366-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phospholipase D was first described in plant tissue but has recently been shown to occur in mammalian cells where it is activated by cell surface receptors. Its mode of activation by receptors in unclear. Biochemical studies suggest that it may occur downstream of other effector proteins and that small GTP-dependent regulatory proteins may be involved. The sequence in a non-designated region of mammalian phospholipase D1 and 2 shows similarity to a structural domain that is present in signalling proteins that are regulated by protein kinases or heterotrimeric G-proteins. Mammalian phospholipase D has structural similarities with other lipid signalling phospholipases and thus may be regulated by receptors in an analogous fashion.

【 授权许可】

Unknown