Structural features of single amino acid repeats in proteins

FEBS Letters

Palau, Jaume²  Subirana, Juan A¹ 

[1] Department d'Enginyeria Quı́mica, ETSEIB, Universitat Politècnica de Catalunya, Av. Diagonal 647, E-08028 Barcelona, Spain;Unitat de Biotecnologia Computacional, Departament de Bioquı́mica i Biotecnologia, Universitat Rovira i Virgili, E-43005 Tarragona, Spain

关键词: Amino acid sequence;    Protein structure;    Nucleotide sequence;    Glutamine;    Neurological disease;    Protein aggregation;   

DOI  :  10.1016/S0014-5793(99)00310-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Single amino acid repeats are found in different kinds of proteins. Some of these repeats are pathogenic. It is striking that some amino acids are able to form such repeats, but other amino acids are not. We suggest an explanation for this fact based on the different tendency of each amino acid to form aggregates. Aggregation may be due to the formation of incipient lamellar crystals as they have been described in poly-α-amino acids and in most synthetic polymers.

【 授权许可】

Unknown