PPARγ activators down‐regulate the expression of PPARγ in 3T3‐L1 adipocytes

FEBS Letters

Camp, Heidi S²  Tafuri, Sherrie R¹  Whitton, Amy L¹ 

[1] Department of Molecular Biology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA;Department of Cell Biology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA

关键词: PPAR;    Desensitization;    Troglitazone;    Anti-diabetic;   

DOI  :  10.1016/S0014-5793(99)00268-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcriptional activation of PPARγ by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and after 3T3-L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARγ proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARγ mRNA. These data suggest that in 3T3-L1 cells, the expression of PPARγ is auto-regulated.

【 授权许可】

Unknown