Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig

The Japanese Journal of Pharmacology

Tsuyoshi Watanabe¹  Junko Kimura²  Shigeatsu Hashimoto¹  Yoko Katoh¹ 

[1] Department of Internal Medicine III,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan;Department of Pharmacology,Fukushima Medical University,School of Medicine,1 Hikarigaoka,Fukushima 960-1295,Japan

关键词: Troglitazone;    Ca2+ channel;    Cardiac myocyte;    Patch-clamp;    Diabetes;   

DOI  :  10.1254/jjp.82.102

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(30)Cited-By(4)We investigated the effects of troglitazone, a new orally active hypoglycemic agent, on the voltage-dependent L-type Ca2+ current in single cardiac ventricular myocytes of guinea pigs by the whole-cell voltage clamp technique.Troglitazone blocked the Ca2+ currents in a concentration-dependent manner.The inhibitory effect was more potent at the holding potential(HP)of −50mV than at −80mV.The half-maximum inhibiting concentration(IC50)of troglitazone was 0.8μM with the Hill coefficient of 0.84 at −50mV HP.In contrast, the IC50 value was higher than 10μM at −80mV HP.These results suggest that troglitazone at therapeutic concentrations inhibit the Ca2+ channels and may exert cardioprotective effects in diabetic conditions.

【 授权许可】

Unknown