Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

FEBS Letters

Tanno, Yoshihiro²  Kiyosawa, Hidenori²  Wanaka, Akio²  Kanazawa, Ken-ya²  Yokoya, Sachihiko²  Takeda, Junko²  Tojo, Michiko²  Ikeda, Hisami¹  Honma, Yutaka²  Mori, Tetsuji²  Nikaido, Takuya²  Oguri, Atsushi²  Kawabata, Isao¹ 

[1] Department of Laboratory Medicine, Asahikawa Medical College, Nisikagura 4-5, Asahikawa 078-8307, Japan;Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan

关键词: Ikaros family;    Molecular cloning;    Zn finger;    Transcription factor;    Nervous system;    Development;   

DOI  :  10.1016/S0014-5793(99)00265-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We identified a novel member of the Ikaros gene family, which has critical roles in the development of lymphoid lineages. This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system. Eos protein could interact with itself and Ikaros protein through its C-terminal portion in the yeast two hybrid assay. These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue.

【 授权许可】

Unknown