Submitochondrial and subcellular distributions of the carnitine‐acylcarnitine carrier

FEBS Letters

Fraser, Fiona¹  Zammit, Victor A¹ 

[1] Hannah Research Institute, Ayr, Scotland KA6 5HL, UK

关键词: Carnitine;    Carnitine-acylcarnitine translocase;    Carnitine palmitoyltransferase;    Mitochondria;    Contact site;    Peroxisome;    Microsome;   

DOI  :  10.1016/S0014-5793(99)00095-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The submitochondrial and subcellular distributions of the carnitine-acylcarnitine translocase (CAC) have been studied. CAC is enriched to a much lesser extent than the carnitine palmitoyltransferases within the contact sites of mitochondria. A high-abundance protein of identical molecular size as the mitochondrial CAC that is immunoreactive with an anti-peptide antibody raised against a linear epitope of mitochondrial CAC is present in peroxisomes but not in microsomes. This suggests that CAC is targeted to at least two different locations within the liver cell and that acylcarnitine transport into peroxisomes is CAC mediated.

【 授权许可】

Unknown