Expression of uncoupling protein‐3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle

FEBS Letters

Boss, O¹  Lanni, A³  Goglia, F²  Lombardi, A²  Moreno, M²  Beneduce, L²  Giacobino, J.P¹  Muzzin, P¹ 

[1] Department of Medical Biochemistry, Faculty of Medicine, University of Geneva 1, Geneva, Switzerland;Dipartimento di Fisiologia Generale ed Ambientale, Via Mezzocannone 8, I-80134, Napoli, Italy;Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli, Caserta, Italy

关键词: Uncoupling protein;    Thyroid hormone;    Skeletal muscle;    Mitochondrion;    Membrane potential;    UCP1;    uncoupling protein-1;    UCP2;    uncoupling protein-2;    UCP3;    uncoupling protein-3;    T3;    triiodothyronine;    PTU;    6-n-propylthiouracil;    IOP;    iopanoic acid;    ΔΨ;    mitochondrial transmembrane electric potential difference;    State 3;    respiratory state in which ATP synthesis is at maximal rate;    State 4;    respiratory state in which there is no ATP synthesis;    RCR;    respiratory control ratio;   

DOI  :  10.1016/S0014-5793(99)00061-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity. UCP3 mRNA expression increased strongly during the hypothyroid-hyperthyroid transition. The rank order of mitochondrial State 3 and State 4 respiration rates was hypothyroid

【 授权许可】

Unknown