Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP‐dependent Lon protease

FEBS Letters

Chloupkova, Maria¹  Sokolikova, Barbora¹  Luciakova, Katarina¹  Nelson, B.Dean² 

[1] Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, SK-833 91 Bratislava, Slovak Republic;Department of Biochemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden

关键词: ATP-dependent protease;    Intramitochondrial proteolysis;    Mitochondrial biogenesis;    T3;    triiodothyronine;   

DOI  :  10.1016/S0014-5793(99)00058-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rats bearing the Zajdela hepatoma tumor and T3-treated hypothyroid rats were used to study the role of protein degradation in the process of mitochondrial biogenesis. It was shown that the activity, protein and mRNA levels of the ATP-dependent Lon protease increased in rapidly growing Zajdela hepatoma cells. The increase in the rate of mitochondrial biogenesis by thyroid hormone was similarly accompanied by enhanced expression of the Lon protease. The results imply that mitochondrial biogenesis in mammalian cells is, at least partially, regulated by the matrix Lon protease.

【 授权许可】

Unknown