期刊论文详细信息
FEBS Letters | |
Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3‐kinase in human neutrophils | |
Horiuchi, Hisanori1  Kita, Toru1  Arai, Hidenori1  Nishioka, Hiroaki1  | |
[1] Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan | |
关键词: Lysophosphatidylcholine; Superoxide anion; Phosphatidylinositol 3-kinase; Protein kinase C; Neutrophil; LPC; lysophosphatidylcholine; O⋅− 2; superoxide anions; PI3 kinase; phosphatidylinositol 3-kinase; PKC; protein kinase C; PC; phosphatidylcholine; PMA; phorbol 12-myristate 13-acetate; fMLP; formyl-methionyl-leucyl-phenylalanine; SOD; superoxide dismutase; OD; optical density; PBS; phosphate-buffered saline; FACS; fluorescence-activated cell sorter; PI; phosphatidylinositol; LPA; lysophosphatidic acid; PI3P; phosphatidylinositol 3-phosphate; LDL; low density lipoprotein; | |
DOI : 10.1016/S0014-5793(98)01526-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Lysophosphatidylcholine (LPC) accumulates in inflammatory tissues, where neutrophils are recruited to generate superoxide anions (O⋅− 2). Here, we show that LPC stimulates O⋅− 2 generation in human neutrophils and that the activity is inhibited with phosphatidylinositol 3-kinase (PI3 kinase) inhibitors, but not with protein kinase C (PKC) inhibitors. Furthermore, we demonstrate that LPC activates PI3 kinase in neutrophils. Thus, LPC might contribute to host defense by generating O⋅− 2 in neutrophils through PI3 kinase activation, but not through PKC activation.
【 授权许可】
Unknown
【 预 览 】
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RO201912020306979ZK.pdf | 153KB | download |