FEBS Letters | |
Molecular analysis of regulation of gene expression of the human erythroid anion exchanger (AE) 1 | |
Philipp, Stephan1  Kneussel, Matthias1  Appelhans, Heribert1  König, Jörg1  | |
[1] Max-Planck-Institut für Biophysik, Heinrich-Hoffmann-Str. 7, D-60528 Frankfurt, Germany | |
关键词: Band 3; Anion exchanger 1; Erythroid specific expression; CT-rich region; Red blood cell maturation; | |
DOI : 10.1016/S0014-5793(98)01326-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The anion exchange protein AE1 is the most abundant membrane protein in human erythrocytes mediating the electroneutral chloride/bicarbonate exchange. We identified a promoter region in the 5′ flanking region of the human AE1 gene which controls transcription in a cell type independent manner. In addition a second, distal promoter element mediates gene expression only in erythroid cells and in dependence upon differentiation. Within this distal promoter region we defined a 44 bp sequence containing a novel CT-rich motif with very strong promoter activity whereas a second 28 bp segment suppresses gene expression.
【 授权许可】
Unknown
【 预 览 】
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