Molecular analysis of regulation of gene expression of the human erythroid anion exchanger (AE) 1

FEBS Letters

Philipp, Stephan¹  Kneussel, Matthias¹  Appelhans, Heribert¹  König, Jörg¹ 

[1] Max-Planck-Institut für Biophysik, Heinrich-Hoffmann-Str. 7, D-60528 Frankfurt, Germany

关键词: Band 3;    Anion exchanger 1;    Erythroid specific expression;    CT-rich region;    Red blood cell maturation;   

DOI  :  10.1016/S0014-5793(98)01326-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The anion exchange protein AE1 is the most abundant membrane protein in human erythrocytes mediating the electroneutral chloride/bicarbonate exchange. We identified a promoter region in the 5′ flanking region of the human AE1 gene which controls transcription in a cell type independent manner. In addition a second, distal promoter element mediates gene expression only in erythroid cells and in dependence upon differentiation. Within this distal promoter region we defined a 44 bp sequence containing a novel CT-rich motif with very strong promoter activity whereas a second 28 bp segment suppresses gene expression.

【 授权许可】

Unknown