Tyrosine kinases in normal human blood cells

FEBS Letters

Varshney, Grish C.¹  Phan-Dinh-Tuy, Françoise¹  Kahn, Axel¹ 

[1] Inserm U 129, 24 rue du Fg St Jacques, 75674 Paris Cedex 14, France

关键词: (Platelet;    Red blood cell);    Tyrosine kinase;    p60c-src;    Band 3;    Differentiation;   

DOI  :  10.1016/0014-5793(86)80873-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The major tyrosine kinase from platelets was purified as a 51 kDa active enzyme which was shown to be a degradation product of the protooncogene product p60^c-src. Immuno-depletion experiments using a monoclonal antibody recognizing p60^c-src failed to remove band 3 phosphorylating activity from red blood cell membranes. The erythrocyte tyrosine kinase was not at all immunoprecipitated by this antibody under conditions where the platelet enzyme was immunoprecipitated.

【 授权许可】

Unknown