The mechanism of proton transport mediated by mitochondrial uncoupling proteins

FEBS Letters

Jabůrek, Martin¹  Garlid, Keith D.¹  Ježek, Petr² 

[1] Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, P.O. Box 91000, Portland, OR 97291-1000, USA;Department of Membrane Transport Biophysics, Institute of Physiology, Academy of Sciences of the Czech Republic, Vı́deňská 1083, CZ 142220 Prague, Czech Republic

关键词: Uncoupling protein;    Fatty acid;    H+ transport;    Chloride transport;    Mutagenesis;    UCP;    uncoupling protein;    FA;    fatty acids;    PN;    purine nucleotides;    BAT;    brown adipose tissue;   

DOI  :  10.1016/S0014-5793(98)01246-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effort to understand the mechanism of uncoupling by UCP has devolved into two models – the fatty acid protonophore model and the proton buffering model. Evidence for each hypothesis is summarized and evaluated. We also evaluate the obligatory requirement for fatty acids in UCP1-mediated uncoupling and the question of fatty acid affinity for UCP1. The structural bases of UCP transport function and nucleotide inhibition are discussed in light of recent mutagenesis studies and in relationship to the sequences of newly discovered UCPs.

【 授权许可】

Unknown