Synergistic action of R‐Ras and IGF‐1 on Bcl‐xL expression and caspase‐3 inhibition in BaF3 cells: R‐Ras and IGF‐1 control distinct anti‐apoptotic kinase pathways

FEBS Letters

Kaziro, Yoshito¹  Koide, Hiroshi¹  Suzuki, Jotaro¹ 

[1] Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226, Japan

关键词: R-Ras;    Apoptosis;    Insulin-like growth factor-1;    Akt;    Mitogen-activated protein kinase;    Bcl-x;   

DOI  :  10.1016/S0014-5793(98)01213-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

R-Ras and insulin-like growth factor-1 (IGF-1) synergistically inhibit apoptosis of BaF3 cells upon interleukin-3 deprivation. To characterize the mechanism of this synergistic inhibition, we examined the effect of R-Ras and IGF-1 on several apoptosis-related proteins. Extracellular signal-regulated kinase (ERK) was activated by IGF-1, but not by R-Ras. In contrast, Akt was activated strongly by R-Ras, but weakly by IGF-1. It was also found that R-Ras and IGF-1 cooperatively induced Bcl-xL expression and inhibited caspase-3 activation.

【 授权许可】

Unknown