期刊论文详细信息
FEBS Letters | |
Growth factor protection against cytokine‐induced apoptosis in neonatal rat islets of Langerhans: role of Fas | |
Harrison, M.2  Green, I.C.2  Green, M.H.L.3  Dunger, A.M.1  John, N.2  Mabley, J.2  Berg, S.1  | |
[1] Institut für Diabetes ‘Gerhardt Katsch’, Karlsburg, Germany;Department of Biochemistry, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, E. Sussex, UK;MRC Cell Mutation Unit, University of Sussex, Brighton BN1 9RR, UK | |
关键词: Growth factor; Cytokine; Fas; Apoptosis; Islet of Langerhans; | |
DOI : 10.1016/S0014-5793(98)01051-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Treatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1β 10−10 M, tumour necrosis factor-α 10−10 M, interferon-γ 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2. Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10−8 M) gave only partial protection against cell killing, but prevented the Fas-mediated component. In the absence of cytokine treatment, Fas-mediated killing was not observed.
【 授权许可】
Unknown
【 预 览 】
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