Age‐related increased susceptibility of high‐density lipoproteins (HDL) to in vitro oxidation induced by γ‐radiolysis of water

FEBS Letters

Fülöp, Tamàs¹  Jay-Gerin, Jean-Paul²  Khalil, Abdelouahed¹ 

[1]Laboratoire de Biogérontologie, Institut Universitaire de Gériatrie de Sherbrooke, 1036, rue Belvédère sud, Sherbrooke, Qué. J1H 4C4, Canada

[2]Département de Médecine Nucléaire et de Radiobiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Qué. J1H 5N4, Canada

关键词: High density lipoprotein;    γ-Radiolysis;    Oxygen free radical;    Aging;    Vitamin E;    Conjugated diene;    Thiobarbituric acid-reactive substance;    Apolipoprotein A-I/A-II;   

DOI  :  10.1016/S0014-5793(98)01058-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the present study, we investigated the age-related susceptibility of high-density lipoproteins (HDL) to oxidation. HDL were obtained from healthy, normolipidemic young, middle-aged and elderly subjects. Oxidation of HDL was induced in vitro by oxygen free radicals generated by water γ-radiolysis, and followed by the decrease of endogenous vitamin E and the formation of conjugated dienes and thiobarbituric acid-reactive substances, as well as the alterations of apolipoproteins A-I/A-II. The resistance of HDL to oxidation, evaluated by the length of the lag phase, decreased with aging. This increased oxidizability of HDL with aging could have a dramatic impact on the development of atherosclerosis in the elderly population.

【 授权许可】

Unknown