Increased susceptibility of low‐density lipoprotein (LDL) to oxidation by γ‐radiolysis with age

FEBS Letters

Lacombe, Guy³  Wagner, J.Richard²  Fülöp, Tamàs³  Dangoisse, Vincent¹  Khalil, Abdelouahed³ 

[1] Service de Cardiologie, Université de Sherbrooke, Faculté de Médicine, Institut Universitaire de Gériatrie, Sherbrooke, Qué., Canada;Department of Nuclear Medicine and Radiobiology, Faculté de Médicine, Institut Universitaire de Gériatrie, Sherbrooke, Qué., Canada;Department of Internal Medicine and Centre de Recherche en Gérontologie et Gériatrie, Faculté de Médicine, Institut Universitaire de Gériatrie, 1036 rue Belvédère sud, Sherbrooke, Qué. J1H 4C4, Canada

关键词: LDL;    γ-Radiolysis;    Aging;    Thiobarbituric acid reactive substances;    Vitamin E;   

DOI  :  10.1016/0014-5793(96)00781-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The susceptibility to oxidation of freshly isolated LDL from healthy normolipidemic individuals in three age groups was estimated by exposure of LDL to ionizing radiation followed by analyses of vitamin E, TBARS, conjugated dienes, and fluorescent products. The results clearly showed that LDL from elderly subjects was the most susceptible to oxidative damage in vitro. In particular, the greater susceptibility of LDL from elderly subjects in comparison to that from young subjects may be attributed to the much lower (4-fold) concentration of LDL vitamin E in the elderly subjects. The present study reinforces the notion that the susceptibility of LDL to oxidation increases with age.

【 授权许可】

Unknown