Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae

FEBS Letters

Valencia, Alfonso¹  Garcia-Ranea, Juan Antonio¹ 

[1] Protein Design Group, CNB-CSIC, Cantoblanco, E-28049 Madrid, Spain

关键词: Ras;    p21;    Yeast;    Genome;    Saccharomyces cerevisiae;    ORF;    open reading frame;    SW;    SwissProt data base;    mYr;    million years;   

DOI  :  10.1016/S0014-5793(98)00967-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras-p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt-rab, ten proteins with different roles in intracellular trafficking; arf-sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis.

【 授权许可】

Unknown