The relationship between synonymous codon usage and protein structure

FEBS Letters

Dafu, Ding¹  Tao, Xie¹ 

[1] Shanghai Institute of Biochemistry, Academia Sinica, 320 Yue Yang Road, Shanghai 200031, People's Republic of China

关键词: Synonymous codon usage;    Protein secondary structure;    Translation rate;    Protein folding;   

DOI  :  10.1016/S0014-5793(98)00955-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hypothesis that synonymous codon usage is related to protein three-dimensional structure is examined by investigating the correlation between synonymous codon usage and protein secondary structure. All except two codons in E. coli show the same secondary structural preference for alpha-helix, beta-strand or coil as that of amino acids to be encoded by the respective codons, while 17 codons show secondary structural bias in mammalian proteins. The results indicate that there is no significant correlation between synonymous codon usage and protein secondary structure in E. coli, but there is a correlation in mammals. It could be deduced that synonymous codons carry much less structural information in prokaryotes than in eukaryotes due to their divergent evolutionary mechanism.

【 授权许可】

Unknown