Non‐random usage of ‘degenerate’ codons is related to protein three‐dimensional structure

FEBS Letters

Neidle, Stephen²  Krasheninnikov, Igor A.¹  Adzhubeib, Ivan A.²  Adzhubei, Alexei A.² 

[1] Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, 119899 Moscow, Russia;CRC Biomolecular Structure Unit, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK

关键词: Synonymous codon usage;    mRNA sequence;    Protein secondary structure;    Sequence-structure relationship;    Cotranslational folding;   

DOI  :  10.1016/S0014-5793(96)01287-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report an analysis of a novel sequence-structure database of mammalian proteins incorporating nucleotide sequences of the exon regions of their genes together with protein sequence and structural information. We find that synonymous codon families (i.e. coding the same residue) have non-random codon distribution frequencies between protein secondary structure types. Their structural preferences are related to the third, ‘silent’ nucleotide position in a codon. We also find that some synonymous codons show very different or even opposite structural preferences at the N- or C-termini of structure fragments, relative to those observed for their amino acid residues.

【 授权许可】

Unknown