Expression of matrix Gla protein (MGP) in an in vitro model of vascular calcification

FEBS Letters

Mori, Katsuhito¹  Morii, Hirotoshi¹  Nishizawa, Yoshiki¹  Shioi, Atsushi¹  Jono, Shuichi¹ 

[1] Second Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545-8586, Japan

关键词: Matrix Gla protein;    β-Glycerophosphate;    Vascular calcification;    Atherosclerosis;    Vascular smooth muscle cell;    Bisphosphonate;    MGP;    matrix Gla protein;    BVSMC;    bovine vascular smooth muscle cells;    β-GP;    β-glycerophosphate;    EHDP;    etidronate;   

DOI  :  10.1016/S0014-5793(98)00870-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To investigate the role of matrix Gla protein (MGP), which can bind mineral ions through γ-carboxylated glutamic acid residues, in vascular calcification, we examined the expression of MGP in an in vitro calcification model by using bovine vascular smooth muscle cells (BVSMC). The expression of MGP mRNA was decreased during BVSMC calcification and its levels were inversely correlated with the quantities of BVSMC calcification. MGP mRNA expression was restored to the level of uncalcified control by inhibiting BVSMC calcification with bisphosphonates. These data suggest that the expression of MGP gene is modulated in the development of vascular calcification.

【 授权许可】

Unknown