Lipophilin, a novel heterodimeric protein of human tears

FEBS Letters

Dinh, Nhu Nguyen¹  Glasgow, Ben J²  Martin, Daniel¹  Abduragimov, Adil²  Qu, Xiao-Dan¹  Lehrer, Robert I¹  Xu, Guorong¹ 

[1]Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA

[2]Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90095, USA

关键词: Tears;    Uteroglobin;    Prostatein;    Estramustine-binding protein;   

DOI  :  10.1016/S0014-5793(98)00852-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; pI, 9.47) was homologous to the C1 and C2 components of prostatein (‘estramustine-binding protein'), the major secreted protein of rat prostate. Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. Tear lipophilins A and C expand the roster of human uteroglobin superfamily members and provide models for exploring these typically steroid-regulated and steroid-binding molecules.

【 授权许可】

Unknown