Evidence that progesterone binding uteroglobin is similar to myosin alkali light chain

FEBS Letters

Baker, Michael E.¹ 

[1] Department of Medicine, M-023, University of California, San Diego, La Jolla, CA 92093, USA

关键词: Calcium-modulated protein;    Myosin;    Uteroglobin;    Progesterone;    Copper;    Prostatic steroid binding protein;   

DOI  :  10.1016/0014-5793(85)81021-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using a computer program designed to detect evolutionary relationships between proteins, I find that exon 2 of rabbit uteroglobin, a progesterone binder, and part of myosin alkali light chain have a comparison score that is 7.2 standard deviations higher than that obtained with a comparison of randomized sequences of these proteins. The probability (p) of getting this score by chance is less than 10⁻¹². This theoretical finding that these sequences are similar has led to the experimental finding that copper, calcium and the tranquilizer trifluoperazine, a calmodulin binding ligand, affect progesterone binding to uteroglobin.

【 授权许可】

Unknown