3‐Aminobenzamide inhibition of protein kinase C at a cellular level

FEBS Letters

Azzi, Angelo³  Cantoni, Orazio¹  Palomba, Letizia¹  Ricciarelli, Roberta² 

[1] Istituto di Farmacologia e Farmacognosia, Università di Urbino, Via S. Chiara 27, I-61029 Urbino, Italy;Dipartimento di Medicina Sperimentale, Università di Genova, via L.B. Alberti 2, 16132 Genova, Italy;Institut für Biochemie und Molekularbiologie, Universtät Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland

关键词: 3-Aminobenzamide;    Apoptosis;    Protein kinase C inhibition;    Poly-(ADP-ribose)-polymerase;   

DOI  :  10.1016/S0014-5793(98)00811-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

3-Aminobenzamide, a known inhibitor of poly-(ADP-ribose)-polymerase has been found in the cell line U-937 to inhibit protein kinase C at the same concentration as poly-(ADP-ribose)-polymerase. 3-Aminobenzamide was not able, however, to inhibit the isolated enzyme. An indirect mechanism of protein kinase C inhibition is proposed.

【 授权许可】

Unknown