Somatic and germline clone analysis in mutants of the S‐adenosylmethionine synthetase encoding gene in Drosophila melanogaster

FEBS Letters

Rasmuson-Lestander, Åsa¹  Larsson, Jan¹ 

[1] Department of Genetics, Umeå University, S-901 87 Umeå, Sweden

关键词: S-Adenosylmethionine synthetase;    Polyamine synthesis;    Protein synthesis;    Drosophila melanogaster;   

DOI  :  10.1016/S0014-5793(98)00408-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have analysed the phenotypic consequences of homozygous mutant clones in the S-adenosylmethionine synthetase encoding gene in Drosophila melanogaster. The results suggest that SamS function is required for cell proliferation/growth in embryonic/early larval cells and during development of imaginal disc cells. Homozygous SamS germline clones can, however, develop and give rise to viable heterozygous offspring. This offspring expresses a Minute-like phenotype. We suggest that this phenotype is caused by an obstruction of the polyamine biosynthesis.

【 授权许可】

Unknown