Protection against apoptosis by monoamine oxidase A inhibitors

FEBS Letters

Matarrese, P³  Ciaccio, A²  Malorni, W³  Agostinelli, E²  Mondovi', B²  Giammarioli, A.M³  Grassilli, E¹  Pietrangeli, P² 

[1] Department of General Pathology, University of Modena, Modena, Italy;Department of Biochemical Sciences and CNR Center of Molecular Biology, University of Rome `La Sapienza', Rome, Italy;Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy

关键词: Apoptosis;    Mitochondrial membrane potential;    Amine oxidase;   

DOI  :  10.1016/S0014-5793(98)00315-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis. This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. pargyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis.

【 授权许可】

Unknown