Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF

FEBS Letters

Cooney, A.J²  Agoulnik, I.Y³  Cho, Y¹  Kieback, D.G³  Niederberger, C¹ 

[1] Department of Urology, University of Illinois at Chicago, 840 South Wood St., Chicago, IL 60612, USA;Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA;Department of Obstetrics and Gynecology, 8550 Fannin, Houston, TX 77005, USA

关键词: Orphan receptor;    Germ cell nuclear factor;   

DOI  :  10.1016/S0014-5793(98)00142-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily. We report the cloning of a cDNA encoding a new variant of human GCNF from human testis and its expression analysis. Southern blot analysis of the human genomic DNA indicates that the GCNF gene is not closely related to other members within the nuclear receptor superfamily. Chromosomal localization of the GCNF gene shows that the gene is located on chromosome 9 at the locus q33–34.1. In situ hybridization analysis of GCNF expression in the testis shows that human GCNF is expressed exclusively in germ cells.

【 授权许可】

Unknown