The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes

FEBS Letters

Benavente, Ricardo²  Schneider-Hirsch, Stefan¹  Maelicke, Alfred¹  Reinhardt, Sigrid¹  Bauer, Uta-Maria¹ 

[1] Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Medical School, Duesbergweg 6, D-55099 Mainz, Germany;Department of Cell and Developmental Biology, Theodor-Boveri Institute (Biocenter), University of Würzburg, Am Hubland, D-97074 Würzburg, Germany

关键词: Germ cell nuclear factor;    Neuronal cell nuclear factor;    Retinoid receptor-related testis-associated receptor;    Nuclear orphan receptor;    Spermatogenesis;    XY body;   

DOI  :  10.1016/S0014-5793(98)01327-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have studied the expression of the nuclear orphan receptor GCNF (germ cell nuclear factor) on the mRNA and protein level in pubertal and adult mouse testes. We show by Northern and Western blot analyses and by in situ hybridization that GCNF is expressed in spermatocytes and round spermatids of adult mouse testis suggesting that GCNF may be a transcriptional regulator of spermatogenesis. Since the GCNF protein is accumulated in the XY body of late pachytene spermatocytes, it may be involved in transcriptional inactivation of sex chromosomes.

【 授权许可】

Unknown