CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s)

FEBS Letters

Aso, Takeshi⁴  Hirai, Hiroyuki¹  Nakamura, Masataka²  Takano, Shoichi¹  Sugamura, Kazuo³  Tanaka, Kazuya¹  Nagata, Kinya¹  Ogawa, Kazuyuki¹ 

[1] Research and Development Center, BioMedical Laboratories, Inc., 1361-1 Matoba, Kawagoe, Saitama 350-1101, Japan;Human Gene Sciences Center, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan;Department of Microbiology and Immunology, Tohoku University School of Medicine, Aoba-ku, Sendai, Miyagi 980-8575, Japan;Department of Obstetrics and Gynecology School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan

关键词: Orphan receptor;    Th2;    Basophil;    Eosinophil;    Ligand producer;    Mast cell;   

DOI  :  10.1016/S0014-5793(99)01251-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand. When stimulated with an anti-FcϵR1 antibody, cord blood-derived mast cells secreted factor(s) that induced Ca²⁺ mobilization in CRTH2-expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions.

【 授权许可】

Unknown