The effect of activin and FSH on the differentiation of rat granulosa cells

FEBS Letters

Kishi, Hiroshi²  Kameda, Takashi²  Tano, Mari²  Minegishi, Takashi²  Miyamoto, Kaoru¹  Ibuki, Yoshito² 

[1] Biosignal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371, Japan;Department of Obstetrics and Gynecology, Gunma University School of Medicine, Gunma University, Maebashi, Gunma 371, Japan

关键词: Activin;    Follicle-stimulating hormone;    Granulosa cell;    Follicle-stimulating hormone receptor;    Luteinizing hormone/human chorionic gonadotropin receptor;   

DOI  :  10.1016/S0014-5793(98)00023-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The differentiation of granulosa cells is regulated by follicle-stimulating hormone (FSH) and local ovarian factors. To further analyze the role of FSH and activin in this process, we have examined the effect of FSH and activin on FSH and luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor induction in granulosa cells. Granulosa cells from diethylstilbestrol (DES)-primed immature rats produce activin and maintain FSH receptor without LH/hCG receptor expression in the absence of FSH. On the other hand, FSH induced granulosa cells to differentiate into more mature granulosa cells in which higher LH/hCG receptor expression and diminished activin production were observed.

【 授权许可】

Unknown