FEBS Letters | |
Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori | |
Morishima, Isao1  Inoue, Kenji1  Matsuo, Noriyuki1  Yamano, Yoshiaki1  | |
[1] Department of Biochemistry and Biotechnology, Faculty of Agriculture, Tottori University, Tottori 680, Japan | |
关键词: Eicosanoid; Cecropin; Lysozyme; Peptidoglycan; Silkworm; Insect immunity; SPG; soluble peptidoglycan; DMSO; dimethyl sulfoxide; BPB; p-bromophenacylbromide; NDGA; nordihydroguaiaretic acid; PLA2; phospholipase A2; | |
DOI : 10.1016/S0014-5793(97)01418-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The expression of cecropin and lysozyme genes is induced in response to bacterial peptidoglycan in the fat body of the silkworm, Bombyx mori. Specific inhibitors of either phospholipase A2, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cultured fat body as detected by means of Northern hybridization. Arachidonic acid injected into the larvae induces the expression of the cecropin and lysozyme genes. The findings support the idea that eicosanoids mediate some process leading to the expression of immune genes in the fat body following recognition of peptidoglycan as a signal for invading bacteria.
【 授权许可】
Unknown
【 预 览 】
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