Eicosanoids mediate induction of immune genes in the fat body of the silkworm, Bombyx mori

FEBS Letters

Morishima, Isao¹  Inoue, Kenji¹  Matsuo, Noriyuki¹  Yamano, Yoshiaki¹ 

[1] Department of Biochemistry and Biotechnology, Faculty of Agriculture, Tottori University, Tottori 680, Japan

关键词: Eicosanoid;    Cecropin;    Lysozyme;    Peptidoglycan;    Silkworm;    Insect immunity;    SPG;    soluble peptidoglycan;    DMSO;    dimethyl sulfoxide;    BPB;    p-bromophenacylbromide;    NDGA;    nordihydroguaiaretic acid;    PLA2;    phospholipase A2;   

DOI  :  10.1016/S0014-5793(97)01418-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of cecropin and lysozyme genes is induced in response to bacterial peptidoglycan in the fat body of the silkworm, Bombyx mori. Specific inhibitors of either phospholipase A₂, cyclooxygenase or lipoxygenase significantly inhibit the induction of the immune genes both in vivo and in cultured fat body as detected by means of Northern hybridization. Arachidonic acid injected into the larvae induces the expression of the cecropin and lysozyme genes. The findings support the idea that eicosanoids mediate some process leading to the expression of immune genes in the fat body following recognition of peptidoglycan as a signal for invading bacteria.

【 授权许可】

Unknown