Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man

FEBS Letters

van Trijp, John M.P²  Mengelers, Marcel J.B²  Buysman, Michel N.C.P²  Katan, Martijn B¹  v.d. Gaag, Martijn S¹  Hollman, Peter C.H²  de Vries, Jeanne H.M¹ 

[1]Division of Human Nutrition and Epidemiology, Agricultural University, Wageningen, The Netherlands

[2]DLO-State Institute for Quality Control of Agricultural Products (RIKILT-DLO), Bornsesteeg 45, 6708 PD Wageningen, The Netherlands

关键词: Flavonoid glycoside;    Dietary quercetin;    Bioavailability;    Pharmacokinetics;    Human;   

DOI  :  10.1016/S0014-5793(97)01367-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Quercetin is a strong antioxidant and a major dietary flavonoid. Epidemiological studies suggest that consumption of quercetin protects against cardiovascular disease, but its absorption in man is controversial. We fed nine subjects a single large dose of onions, which contain glucose conjugates of quercetin, apples, which contain both glucose and non-glucose quercetin glycosides, or pure quercetin-3-rutinoside, the major quercetin glycoside in tea. Plasma levels were then measured over 36 h. Bioavailability of quercetin from apples and of pure quercetin rutinoside was both 30% relative to onions. Peak levels were achieved less than 0.7 h after ingestion of onions, 2.5 h after apples and 9 h after the rutinoside. Half-lives of elimination were 28 h for onions and 23 h for apples. We conclude that conjugation with glucose enhances absorption from the small gut. Because of the long half-lives of elimination, repeated consumption of quercetin-containing foods will cause accumulation of quercetin in blood.

【 授权许可】

Unknown