Pharmacokinetics of danofloxacin after single dose intravenous, intramuscular and subcutaneous administration to loggerhead turtles Caretta caretta

Diseases of Aquatic Organisms

Alejandro Bayón¹  Ramon Almela¹  Emilio Fernández-Varón¹  Cristina Clavel¹  Carlos M. Cárceles¹  Elisa Escudero¹  Pedro Marín¹ 

关键词: Danofloxacin;    Pharmacokinetics;    Loggerhead turtle;    Bioavailability;    Caretta caretta;   

DOI  :  10.3354/dao01987

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: The single-dose disposition kinetics of the antibiotic danofloxacin were determined in clinically normal loggerhead turtles (n = 6) after intravenous (IV), subcutaneous (SC) and intramuscular (IM) administration of 6 mg kg^–1 bodyweight. Danofloxacin concentrations were determined by high performance liquid chromatography with fluorescence detection. The concentration–time data were analyzed by non-compartmental kinetic methods. Steady-state volume of distribution, and total body clearance of danofloxacin after IV administration were estimated to be 1.02 ± 0.17 l kg^–1 and 0.11 ± 0.01 l h^–1 kg^–1, respectively. Following IM and SC administration, danofloxacin achieved maximum plasma concentrations of 10.25 ± 4.59 and 10.35 ± 4.45 mg l^–1 at 1.20 ± 0.52 and 1.46 ± 0.48 h, respectively. The absolute bioavailabilities after SC and IM routes were 98.72 ± 11.73 and 104.81 ± 14.97%, respectively. Danofloxacin shows a favourable pharmacokinetic profile in loggerhead turtles reflected by parameters such as a long half-life and a high bioavailability following a single dose of 6 mg kg^–1 by IM and SC routes; thus, it is likely that this treatment will be effective in loggerhead turtles with bacterial infections.

【 授权许可】

Unknown