NGF exhibits a pro‐apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFβ1

FEBS Letters

Bono, Françoise¹  Lamarche, Isabelle¹  Herbert, Jean-Marc¹ 

[1] Haemobiology Research Department, Sanofi Recherche, 195 Route d'Espagne, 31036 Toulouse, France

关键词: Smooth muscle cell;    Apoptosis;    NGF;    TGFβ1;   

DOI  :  10.1016/S0014-5793(97)01215-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

These results indicate that, at least in vitro, TGFβ1 can inhibit the pro-apoptotic activity of NGF for SMCs therefore suggesting that TGFβ1 has the capacity to diminish the deleterious consequences of an excitotoxic or ischemic injury that might occur during atherogenesis or following angioplasty.

【 授权许可】

Unknown