Glucokinase is located in secretory granules of pancreatic D‐cells

FEBS Letters

Ito, Yuki¹  Miwa, Ichitomo¹  Yoshie, Sumio²  Nonogaki, Tsunemasa³  Toyoda, Yukiyasu¹  Fujita, Tsuneo² 

[1] Department of Clinical Biochemistry, Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya 468, Japan;Department of Oral Anatomy, Nippon Dental University School of Dentistry at Niigata, Niigata 951, Japan;Department of Pathology, Aichi Medical University, Nagakute-cho, Aichi 480-11, Japan

关键词: Glucokinase;    Pancreatic islet of Langerhans;    Somatostatin;    Secretory granule;    Diabetes mellitus;   

DOI  :  10.1016/S0014-5793(97)01139-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We immunohistochemically examined the distribution of glucokinase in rat pancreatic islets. Glucokinase immunoreactivity under light microscopy was detected in the cytoplasm of somatostatin cells as well as in that of insulin cells. No specific immunoreactivity was detected in glucagon and pancreatic polypeptide cells. In somatostatin cells, glucokinase immunoreactivity was located by electron microscopy exclusively within secretory granules.

【 授权许可】

Unknown