Telethonin, a novel sarcomeric protein of heart and skeletal muscle

FEBS Letters

Lanfranchi, G³  Valle, G³  Tiso, N¹  Faulkner, G²  Trevisan, S³  Pallavicini, A¹  Toppo, S³  Pandolfo, D³  Pacchioni, B³  De Antoni, A¹ 

[1] Dipartimento di Biologia, Università degli Studi di Padova, via Trieste 75, I-35121 Padua, Italy;International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy;CRIBI Biotechnology Centre, Università degli Studi di Padova, via Trieste 75, I-35121 Padua, Italy

关键词: Skeletal muscle;    Sarcomeric protein;    Expressed sequence tag;   

DOI  :  10.1016/S0014-5793(97)01108-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this paper we describe a novel 19 kDa sarcomeric protein named telethonin. The cDNA sequence discloses an open reading frame of 167 amino acids that does not resemble any known protein. Antibodies against a recombinant telethonin fragment were used for Western blot analysis, confirming the presence of this 19 kDa protein in heart and skeletal muscle and revealing an immunofluorescence pattern typical of sarcomeric proteins, overlapping myosin. The frequency of specific cDNA clones in different libraries indicates that the telethonin transcript is amongst the most abundant in skeletal muscle. In human, telethonin maps at 17q12, adjacent to the phenylethanolamine N-methyltransferase gene.

【 授权许可】

Unknown