vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long‐term potentiation and synaptogenesis

FEBS Letters

Ozawa, Fumiko¹  Inokuchi, Kaoru¹  Kato, Akihiko¹  Saitoh, Yoshito¹  Hirai, Keiko¹ 

[1] Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194, Japan

关键词: Long-term potentiation;    Seizure;    Hippocampus;    Gene regulation;    PCR differential display;    LTP;    long-term potentiation;    PTZ;    pentylenetetrazol;    bp;    base pair(s);    CHX;    cycloheximide;    kb;    kilobase(s);    ORF;    open reading frame;    NMDA;    N-methyl-d-aspartate;    HFS;    high-frequency stimulation;    LFS;    low-frequency stimulation;    fEPSP;    field excitatory postsynaptic potential;    i.p.;    intraperitoneal;    G6PDH;    glucose 6-phosphate dehydrogenase;   

DOI  :  10.1016/S0014-5793(97)00775-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

【 授权许可】

Unknown