Increase in activin βA mRNA in rat hippocampus during long‐term potentiation

FEBS Letters

Ozawa, Fumiko²  Hiraia, Keiko²  Hishinuma, Fumio²  Inokuchi, Kaoru²  Kato, Akihiko²  Inoue, Maki¹ 

[1] Department of Physiology II, Azabu University, Sagamihara, Kanagawa 229, Japan;Mitsubishi Kasel Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194, Japan

关键词: mRNA differential display;    Long-term potentiation;    Seizure;    TGF-β superfamily;    Activin;    Synaptic plasticity;    EPSP;    excitatory postsynaptic potential;    G6PDH;    glucose-6-phosphate dehydrogenase;    HFS;    high frequency stimulation;    LTP;    long-term potentiation;    NMDA;    PTZ;    pentylenetetrazol;    RT-PCR;    reverse transcriptase-polymerase chain reaction;    TGF-β;    transforming growth factor-β;   

DOI  :  10.1016/0014-5793(96)00135-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have used mRNA differential display to isolate genes that are induced by neural activity in rat hippocampus. One of these encodes activin βA subunit. Convulsive seizure caused by kainate significantly induced the expression of activin βA mRNA. Furthermore high frequency stimulation (HFS) of perforant pathway, which produced a persistent long-term potentiation (LTP) (> 10 h), caused a marked increase at 3 h in the level of activin βA mRNA at the dentate gyrus of urethane-anesthetized rat. The increase was NMDA receptor-dependent. By contrast the level of inhibin α mRNA was not changed following the induction of LTP. The results suggest a role for activin in maintenance of neural plasticity in the adult brain.

【 授权许可】

Unknown