Alternative activation of transcriptional initiators in Drosophila melanogaster LINE promoters

FEBS Letters

Di Nocera, Pier Paolo¹  Minchiotti, Gabriella¹ 

[1] Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘L. Califano’, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy

关键词: Transcription regulation;    Initiator;    Downstream promoter;    TFIID;    Transcriptional activation;   

DOI  :  10.1016/S0014-5793(97)00689-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the Drosophila I, F and Doc LINEs, basal transcription is ensured by the functional interaction of initiator sequences with intragenic regulatory segments (B regions) which comprise distinct functional modules. Removing the B regions, as changing their composition or location, allowed different activators to stimulate transcription from novel initiators both in Doc and F promoters. The use of distinct initiators plausibly reflects the assembly of transcriptional complexes in which TFIID assumes alternative spatial conformations. The response of I, F and Doc promoters to the same enhancer is significantly influenced by the number, position and type of core elements present.

【 授权许可】

Unknown