The stimulatory effect of negative air ions and hydrogen peroxide on the activity of superoxide dismutase

FEBS Letters

Kaminsky, Yu.G¹  Kondrashova, M.N¹  Stavrovskaya, I.G¹  Kosenko, E.A¹  Sirota, T.V¹ 

[1] Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino 142292, Russia

关键词: Negative air ions;    Superoxide radical;    Superoxide dismutase;    Hydrogen peroxide;    SOD;    superoxide dismutase;    NAI;    negative air ions;    ESOD;    erythrocyte cytosolic superoxide dismutase;    ESOD-C;    ESOD prepared with control saline;    ESOD-I;    ESOD prepared with saline pretreated with NAI;    NTB;    p-nitrotetrazolium blue;   

DOI  :  10.1016/S0014-5793(97)00651-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of erythrocyte cytosolic superoxide dismutase from rat, bovine, man and duck was considerably increased when measured after preparation or incubation in media pretreated with negative air ions (mostly superoxide) from electroeffluvial ion generator. 0.5–1.0 μM H₂O₂ was found in incubation medium after treatment with air ions. The stimulatory effect of air ions on superoxide dismutase activity was mimicked by addition of 0.5–6 μM H₂O₂. The primary physicochemical mechanism of beneficial biological action of negative air ions is suggested to be related to the stimulation of superoxide dismutase activity by micromolar concentrations of H₂O₂.

【 授权许可】

Unknown