Enhanced oxidizability of ubiquinol and α‐tocopherol during lovastatin treatment

FEBS Letters

Metsä-Ketelä, Timo¹  Malminiemi, Kimmo³  Palomäki, Ari² 

[1] Tampere University, Tampere, Finland;Kanta-Häme Central Hospital, Hämeenlinna, FIN-13530, Finland;Tampere University Hospital, PO Box 2000, Tampere, FIN-33521, Finland

关键词: Antioxidant;    LDL cholesterol;    Lovastatin;    Oxidation;    Ubiquinol;    Vitamin E;   

DOI  :  10.1016/S0014-5793(97)00609-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A double-blinded, placebo-controlled cross-over trial was carried out with 27 hypercholesterolemic men with coronary heart disease. During the 6-week treatment period lovastatin (60 mg/day) decreased fasting serum LDL cholesterol by 45%, LDL phosphorus by 38% and apoB by 33%. Ubiquinol content diminished by 13% as measured per LDL phosphorus. When LDL was oxidized ex vivo with AMVN both LDL ubiquinol and α-tocopherol were exhausted faster after lovastatin treatment compared to placebo, by 24% (P<0.005) and 36% (P<0.0001), respectively. Lag time in copper-induced oxidation of LDL decreased by 7% (P<0.01). This suggests diminished antioxidant-dependent resistance of LDL to the early phase of oxidative stress.

【 授权许可】

Unknown